Viral immunosuppression: disabling the guards

Immunosuppression by viral N proteins

Arenaviruses and Coronaviruses (CoV) are enveloped RNA viruses. The nucleoproteins (N) of these viruses (termed nucleocapsid in CoV) play a key role in the formation of the viral ribonucleoprotein (RNP) complexes and in causing type I interferon (IFN) suppression. The primary function of the N proteins of CoV, such as the severe acute respiratory syndrome coronavirus (SARS-CoV), and of arenavir...

Potentiation of viral carcinogenesis by immunosuppression.

Selective viral immunosuppression of the graft-versus-host reaction

Graft-vs.-host (GVH) reactivity of parental lymph node (LN) cells was assayed by measurements of 3H-thymidine incorporation in vivo in spleens of irradiated F1 recipients. Preincubation of parental LN cells with vesicular stomatitis virus (VSV) for 2 h at 37 degrees C followed by washing resulted in an 85-90% reduction in splenic radioactivity, as did injection of VSV on days 0-2 after recipien...

Change of the Guards

Since Professor Lillemor Hallberg and Professor Karin Dahlberg started the International Journal of Qualitative Studies on Health and Well-being (IJQHW) in 2006 it has developed immensely, not least after 2010 when it became Open Access. With unhindered access to all content, readers in 172 countries have since then accessed the journal’s website in their thousands, and more than 290,000 full-t...

Changing of the guards

. Establishment in 1973 as an organ of the Nordiska Samarbetskommitten för Arktisk Medicinsk Forskning (NoSAMF), reporting to and financed by the Nordic Council of Ministers (NCM). . The dissolution of NoSAMF in 1996 and the transfer of the journal to joint ownership by the Nordic Society for Arctic Medicine (NSAM) and the International Union of Circumpolar Health (IUCH). Editorial and administ...